Endocrine Abstracts

Introduction: Adipocyte fatty acid binding protein (A-FABP) is a fatty acid chaperone that facilitates the efflux of free fatty acid from cytoplasm into circulation. Previous studies show that A-FABP knockout (KO) mice are more susceptible to diet-induced obesity comparing to wild type (WT) littermates. Here we investigate the underlying mechanism of A-FABP in the regulation of diet-induced obesity.Methods: A-FABP KO mice and their WT littermates were fe...

Introduction: Atherosclerosis is a chronic inflammatory arterial disease and is currently one of the most common causes of cardiovascular morbidity and mortality worldwide. Therefore, there is an urgent need to discover new therapeutic targets for treatment of this fatal chronic disease. Fatty acid binding protein 4 (FABP4), a pro-inflammatory adipokine that links obesity with its related metabolic diseases, has been implicated in the development of atherosclerosis. This study...